Pharmaceutical Metrion Biosciences Limited and LifeArc, a leading UK medical research charity, have entered into a collaboration agreement for an ion channel drug discovery project in the field of neuroscience.
The project aims to identify novel selective small molecule modulators of a specific ion channel target, which human patient gene association studies have identified as likely to be involved in neurological pathogenesis.
Dr Edward Stevens, Head of Drug Discovery, Metrion Biosciences, said:?“Metrion has a long standing working relationship with LifeArc, and we are very pleased to be working with the team again on this new project, on a highly promising neuroscience target.”
LifeArc will have responsibility for all new chemical syntheses with Metrion conducting ion channel screening. Metrion will provide support for LifeArc’s medicinal chemistry target optimisation via its extensive suite of drug discovery assays, including high quality automated and conventional electrophysiology, translational neuroscience, and cardiac safety profiling assays.??
The project commenced in January 2019 and will run for an initial period of twelve months, with an option to extend for a further twelve months based upon achievement of mutually agreed criteria. If successful, LifeArc will be responsible for further development of the programme.