With the introduction of the Axio Examiner Fixed Stage Microscope, Carl Zeiss makes electrophysiological experiments easier to set-up and perform. The Axio Examiner’s specially-designed sloping turret maximises the working area on the large stage and allows a working distance of more than 100mm. In addition, the generous open space permits unimpeded access to the experimental area and a high degree of flexibility in configuring options, such as micro-manipulators, pipettes around large specimens. The new system may be especially valuable in neuroscience research for patch clamp experiments on nerve cells, examination of brain sections, and the measurement of cellular electrical signals. Multiphoton imaging is available simply by combining the Axio Examiner fixed stage with the new Zeiss LSM 710 NLO microscope.