With the new CellHesion200, JPK Instruments has created an integrated system for measuring cell-cell and cell-substrate interactions. The CellHesion200 may be integrated with a standard optical inverted microscope in less than a minute to provide the user flexibility and expanding the spectrum of possible control experiments. CellHesion technology provides quantitative and reliably reproducible measurements of the adhesive and stiffness characteristics of living cells. The system delivers precise information about single molecule behavior. Additionally, quantifiable and reproducible data can be produced for a number of important parameters involved in cell adhesion, including single bond partner interactions. CellHesion200 can also be used to determine mechanical characteristics such as cell elasticity or stiffness.