Thermo Fisher Scientific recently launched the Thermo Scientific TSQ Vantage at ASMS 2008. A new LC-MS/MS system that delivers up to 10 times more sensitivity than any other triple quadrupole instrument on the market, it does not produce a commensurate increase in noise. New technical breakthroughs have given the TSQ Vantage unmatched signal-to-noise performance, providing better reproducibility and precision in the quantitative analysis of small molecules, biomolecules and peptides. Many LC-MS/MS systems today claim high sensitivity, but can only deliver on that promise by sacrificing precision, specificity and reproducibility because of high chemical noise levels. The TSQ Vantage offers up to 10 times the signal-to-noise ratio when compared to the TSQ Quantum series and claims to exceed any other triple quadrupole instruments in the field.