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 Now available with an S9 protocol to detect genotoxic metabolites, GreenScreen HC from Gentronix is a human cell-based genotoxicity screening assay used in drug discovery programmes during lead compound optimisation and candidate selection. Potential pharmaceutical compounds which only present a genotoxicity hazard after metabolism, usually by the liver, are known as pro-genotoxins. The utility of Green-Screen HC has now been extended to detect pro-genotoxins as well as all common mechanistic classes of genotoxin including mutagens, clastogens, aneugens, as well as both topoisomerase and polymerase inhibitors. Minimal investment in early genotoxicity screening delivers major time savings, avoids unnecessary animal testing and prevents costly late stage failures of lead drug
compounds through early detection of genotoxic potential.
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