Applied Biosystems has announced that researchers have discovered comprehensive profiles of gene activity from single cells using the SOLiD System, its next-generation genomic analysis platform. The finding represents the first use of any next-generation genomic analysis platform for a hypothesisneutral, genome-wide survey of expressed genes in individual cells. This proprietary research method has the potential to reveal details about cell fate and can potentially accelerate the discovery of biomarkers for a variety of diseases, including cancer. The high sensitivity of the SOLiD System enabled the scientists to generate 75% more, or 5,270 more expressed genes with a single cell compared to microarray techniques. The researchers identified 1,753 novel splice junctions, which have never been detected by microarray techniques at single cell resolution.
Applied Biosystems has announced that researchers have discovered comprehensive profiles of gene activity from single cells using the SOLiD System, its next-generation genomic analysis platform. The finding represents the first use of any next-generation genomic analysis platform for a hypothesisneutral, genome-wide survey of expressed genes in individual cells. This proprietary research method has the potential to reveal details about cell fate and can potentially accelerate the discovery of biomarkers for a variety of diseases, including cancer. The high sensitivity of the SOLiD System enabled the scientists to generate 75% more, or 5,270 more expressed genes with a single cell compared to microarray techniques. The researchers identified 1,753 novel splice junctions, which have never been detected by microarray techniques at single cell resolution.
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