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Genomic technology

 

Applied Biosystems has announced that researchers have discovered comprehensive profiles of gene activity from single cells using the SOLiD System, its next-generation genomic analysis platform. The finding represents the first use of any next-generation genomic analysis platform for a hypothesisneutral, genome-wide survey of expressed genes in individual cells. This proprietary research method has the potential to reveal details about cell fate and can potentially accelerate the discovery of biomarkers for a variety of diseases, including cancer. The high sensitivity of the SOLiD System enabled the scientists to generate 75% more, or 5,270 more expressed genes with a single cell compared to microarray techniques. The researchers identified 1,753 novel splice junctions, which have never been detected by microarray techniques at single cell resolution.

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