The new Zetasizer APS (Auto Plate Sampler) from Malvern Instruments delivers fully automated measurement of protein size, with no compromise in data accuracy or quality. An ideal solution to improve productivity, this dynamic light scattering (DLS) system handles 96- or 384-well microplates, transferring the sample to a closely controlled environment for robust size characterisation. Measurements within this defined environment provide the accuracy and temperature stability needed to deliver consistent, reliable results. The resulting data precision gives access to more applications, particularly those requiring the detection of small amounts of aggregates or the early onset of aggregation. Since the Zetasizer APS can handle virtually all commercially available microwell plates, no special materials are needed avoiding the use of expensive plates with special optical properties.