The Wellcome Trust Sanger Institute, a leading genome research institute, and Applied Biosystems are sequencing a cancer genome and normal DNA from the same individual to comprehensively detect and characterise the genetic changes that occur during the development of the disease. The purpose of this research is to provide the highest resolution picture to date of genetic variation in the development of cancer. In this collaboration, scientists will use five Applied Biosystems SOLiD Systems in an effort to sequence the genomes of a small cell lung cancer cell line and a non-cancerous cell line, and comprehensively cover all of the genomic variations in both cell lines. This project is expected to advance research recently carried out by The Sanger Institute’s Cancer Genome Project.